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A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Dose-Ranging Study Evaluating the Efficacy and Safety of GS-1427 in Adult Participants With Moderately to Severely Active Ulcerative Colitis (UC) (SWIFT)
The goal of this study is to learn if GS-1427 is effective in treating participants with moderate to severe ulcerative colitis. The study will compare participants in different treatment groups treated with GS-1427 with participants treated with placebo. The primary objective of this study is to assess the efficacy of GS-1427, compared with placebo control, in achieving clinical response at Week 12.
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Age
18 Years - 75 Years
Sex
ALL
Healthy Volunteers
No
Medical Condition
Ulcerative Colitis
Gender
N/A
Date
March 2024 - October 2025
Study Type
INTERVENTIONAL
Study Phase
PHASE2
Product
GS-1427, Placebo-to-match GS-1427
Peoria, Arizona, United States, 85381
Camarillo, California, United States, 93010
Garden Grove, California, United States, 92845
Inglewood, California, United States, 90301
La Jolla, California, United States, 92037
Lancaster, California, United States, 93534
Murrieta, California, United States, 92563
Oakland, California, United States, 94609
San Diego, California, United States, 92103
San Diego, California, United States, 92120
Colorado Springs, Colorado, United States, 80907
Hialeah, Florida, United States, 33016
Hollywood, Florida, United States, 33021
Miami, Florida, United States, 33136
Miami, Florida, United States, 33183
New Port Richey, Florida, United States, 34653
Orlando, Florida, United States, 32825
Orlando, Florida, United States, 34741
Tampa, Florida, United States, 33612
Weston, Florida, United States, 33331
Decatur, Georgia, United States, 30033
Snellville, Georgia, United States, 30078
Shreveport, Louisiana, United States, 71105
Baltimore, Maryland, United States, 21224
Chesterfield, Michigan, United States, 48047
Wyoming, Michigan, United States, 49519
Rochester, Minnesota, United States, 55905
Oxford, Mississippi, United States, 38655
Tupelo, Mississippi, United States, 38801
Weldon Spring, Missouri, United States, 63304
Brooklyn, New York, United States, 11215
Manhasset, New York, United States, 11030
New York, New York, United States, 10016
Greenville, North Carolina, United States, 27834
Statesville, North Carolina, United States, 28625
Beavercreek, Ohio, United States, 45440
Cincinnati, Ohio, United States, 45219
Westlake, Ohio, United States, 44145
Hershey, Pennsylvania, United States, 17033
Pottsville, Pennsylvania, United States, 17901
Jackson, Tennessee, United States, 38301
Nashville, Tennessee, United States, 37211
Nashville, Tennessee, United States, 37232
Fredericksburg, Texas, United States, 78624
Georgetown, Texas, United States, 78628
Houston, Texas, United States, 77074
Mansfield, Texas, United States, 76063
San Antonio, Texas, United States, 78212
San Antonio, Texas, United States, 78229
Tyler, Texas, United States, 75701
Charlottesville, Virginia, United States, 22908
Lansdowne Town Center, Virginia, United States, 20176
Roanoke, Virginia, United States, 24014
Sydney, New South Wales, Australia, 2109
South Brisbane, Queensland, Australia, 4101
Woolloongabba, Queensland, Australia, 4102
Woodville, South Australia, Australia, 5011
Clayton, Victoria, Australia, 3168
Epping, Victoria, Australia, 3076
Fitzroy, Victoria, Australia, 3065
Footscray, Victoria, Australia, 3011
Innsbruck, Austria, 6020
Vienna, Austria, 1090
Bonheiden, Belgium, 2820
Kortrijk, Belgium, 8500
Vaughan, Canada, L4L 4Y7
Slany, Czechia, 274 01
Nantes, France, 44000
Pierre-Benite, France, 69495
Tbilisi, Georgia, 112
Halle (Saale), Germany, 06108
Kiel, Germany, 24105
Hong Kong, Hong Kong, 999077
Hong Kong, Hong Kong
Budapest, Hungary, 1085
Budapest, Hungary, 1125
Milano, Italy, 20089
Roma, Italy, 00128
Busan, Korea, Republic of, 48108
Daegu, Korea, Republic of, 41944
Daejeon, Korea, Republic of, 34943
Guri-Si, Korea, Republic of, 471-701
Jongno-Gu, Korea, Republic of, 03181
Nam-Gu, Korea, Republic of, 42415
Seongdong-gu, Korea, Republic of, 4763
Seoul, Korea, Republic of, 05505
Seoul, Korea, Republic of, 6351
Seoul, Korea, Republic of, 6591
Wonju, Korea, Republic of, 220-701
Kelantan, Malaysia, 16150
Kota Kinabalu, Malaysia, 88586
Kuantan, Malaysia, 25100
Kuantan, Malaysia, 25200
Petaling Jaya, Malaysia, 50603
Selangor, Malaysia, 43000
Chisinau, Moldova, Republic of, MD-2025
Katowice, Poland, 40-600
Kraków, Poland, 30-082
Kraków, Poland, 31-501
Ksawerów, Poland, 95-054
Mazowieckie, Poland, 05-500
Poznan, Poland, 61-441
Poznań, Poland, 60-309
Rzeszów, Poland, 35-301
Szczecin, Poland, 71-434
Torun, Poland, 87-100
Tychy, Poland, 43-100
Warsaw, Poland, 00-719
Warsaw, Poland, 00-728
Warszawa, Poland, 00-332
Warszawa, Poland, 03-580
Wroclaw, Poland, 50-008
Wroclaw, Poland, 52416
Wrocław, Poland, 54-144
Bucharest, Romania, 11658
Bucuresti, Romania, 020125
Cluj-Napoca, Romania, 3-5
Timisoara, Romania, 300002
Changhua City, Taiwan, 505
Kaohsiung, Taiwan, 807
Taichung, Taiwan, 404327
Taichung, Taiwan, 40705
Taipei, Taiwan, 100
Taipei, Taiwan, 10449
Taipei, Taiwan, 11217
Taoyuan City, Taiwan, 333
Cambridge, United Kingdom, CB2 0QQ
Cardiff, United Kingdom, CF159SS
Hexham, United Kingdom, NE46 1QJ
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